Evaluation of Antibacterial Activity of Tanzanian Gooseberry (Physalis peruviana) Leaf Extract against Multi-Drug Resistance Escherichia coli and Salmonella typhi
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Date
2024-12-05
Journal Title
Journal ISSN
Volume Title
Publisher
MJRD
Abstract
This study was conducted to evaluate in-vitro antibacterial activities of
methanolic leaf extract of Physalis peruviana growing in Dodoma,
Tanzania, against multidrug-resistant bacteria (Escherichia coli and
Salmonella typhi) using agar well diffusion and standard microdilution
methods. Moreover, leaf extract was screened qualitatively for the
presence of phytoconstituents using standard methods. Methanolicleaf
extract of P. peruviana (from 0.2 mg/mL to 0.4 mg/mL concentrations)
showed antibacterial activity against tested E. coli and S. typhi with
zones of inhibition ranging from 19 to 21 mm and 17.7 to 22 mm,
respectively. The micro-dilution method revealed the minimum
inhibitory concentration of methanolic leaf extract of P. peruviana to be
10 µg/µL and 5 µg/µL for E. coli and S. typhi, respectively. Qualitative
phytochemical analysis of methanolic leaf extract of P. peruviana
identified the presence of tannins, cardiac glycosides, alkaloids,
terpenoids, steroids, flavonoids, and phenols. Methanolic leaf extract of
P. peruviana has antibacterial activity against multidrug-resistant
bacteria (E. coli and S. typhi). This plant may be a promising new source
of future antibiotics that potentially combat the existing problem of
antimicrobial resistance.
Description
This Journal Article was published at Mbeya University of Science and Technology