Biotechnological Innovations to Combat Antimicrobial Resistance and Advance Global Health Equity
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Date
2025-09-05
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MDPI
Abstract
Antimicrobial resistance (AMR) is a growing global health emergency that threatens the
effectiveness of modern medicine, exacerbating healthcare costs, morbidity, and mortal-
ity, particularly in low- and middle-income countries (LMICs). Traditional approaches
to antimicrobial development and stewardship have proven inadequate in curbing the
rapid emergence and spread of resistant pathogens. This review explores cutting-edge
biotechnological innovations as sustainable, precision-based solutions to combat AMR
and promote global health equity. A comprehensive narrative review was conducted
using literature published between 2018 and 2023 from PubMed, ScienceDirect, and Web
of Science. Peer-reviewed studies focusing on novel antimicrobial strategies were the-
matically analyzed, with attention to efficacy, feasibility, and translational readiness. Key
innovations identified include nanotechnology-enhanced antimicrobial delivery, bacterio-
phage therapy, CRISPR-Cas gene editing, immunotherapy, and personalized medicine.
These strategies demonstrated substantial in vitro and in vivo efficacy, such as >90% MRSA
biofilm reduction via silver nanoparticles and 95% carbapenem susceptibility restoration
in E. coli using CRISPR-Cas9. When integrated with machine learning and rapid diagnos-
tics, these approaches enable precision-targeted therapies and data-informed stewardship,
offering scalable solutions adaptable to diverse healthcare systems. Antimicrobial resis-
tance demands urgent, equitable innovation. Integrating biotechnologies like CRISPR,
phage therapy, and nanomedicine with data-driven tools offers promising solutions. To
ensure real-world impact, we recommend establishing regionally tailored translational
research platforms and public–private partnerships as the most effective strategy to scale
innovations and strengthen AMR response in low-resource settings.
Description
This Journal Article was Published by MDPI